Dezvoltarea de soluții inovatoare și tehnologii de fabricație avansată cu laseri, plasmă și radiații pentru rezolvarea problemelor societale – Institutul National pentru Fizica Laserilor, Plasmei si Radiatiei

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Research

The Name Of The Program Core:
Research and advanced technology development of a laser – plasma radiation to space

Acronym: LAPLAS LIVE
Contract no.: 30N/2023

The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society

The code of the project: PN-23 03 01
In charge of the project: Dr - Felix Sima

Four the work packages (WP) the project's aim the specific objectives (OS), as follows:

WP1: Sources, systems and laser or plasma for the fabrication of advanced devices for emerging technologies.

OS1.1: the Development of manufacturing technology in the additive and subtractive source for laser and plasma

WP2: innovation Technologies of production for the energy of the future, for the achievement of sustainable development.

OS2.1: quality control for the power generation/transfer/storage of energy based on the innovative technology of laser/plasma/radiation in a shift towards environment-friendly solutions, and the impact of climate
OS2.2: the Development of mathematical models and methods for the control of the operating parameters for the systems for the production and storage of energy

PL3: an integrated system and advanced technology to improve the quality of your life.

OS3.1: advanced Technologies for the fabrication of laser devices to the medical implant
OS3.2: innovative technology Solutions for the diagnosis and treatment of cancer

WP4: manufacturing Technology, advanced sensors and software sensing for smart agriculture, and public safety.

OS4.1: Technologies for the fabrication of advanced devices senzoristice, and platforms, sensing for agriculture, intelligent, and public safety
OS4.1: technological Solutions for monitoring and controlling the quality of the manufacturing processes of advanced

The results of the aim to develop the models, theoretical, and experimental solution to the validation of the manufacturing know-how, products, and services. Target (T), and the results that we are grouped together, as follows:

WP1: Sources, systems and laser or plasma for the fabrication of advanced devices, technologies, emerging market

Q1.1. The components for the source of the laser and the plasma (the average of the active, two-way mirrors, laser power sources plasma arc)
Q1.2. The assembly and testing of the system, the laser pulses of sub-picosecond
Q1.3. The completion and testing of the sources of the plasma
Q1.4. Stop the processing of the laser
Q1.5. The approval of the internal sources of the laser and the plasma, and accreditation services

WP2: innovation Technologies of production for the energy of the future, for the achievement of sustainable development.

Q2.1. The production of nanofluids for the transfer/dissipation of the energy-based micro-nanostructures have been processed by the techniques of laser/plasma
Q2.2. The development of mathematical models and methods for the control of the operating parameters for the systems for the production and storage of energy
Q2.3. The development of systems for the generation of renewable energy-based micro-nanostructures, obtained by the technique of laser/plasma/radiation
Q2.4. The development of systems for the storage of energy based on the processing of eco-friendly materials, and abundant natural
Q2.5. The development of the state-of-the welding laser beam contact, made of heterogeneous materials, from the composition to the batteries of electric

PL3: an integrated system and advanced technology to improve the quality of your life.

Q3.1. Substrate steel and alloys for coatings, biomimetic devices, implants custom made by 3D printing.
Q3.2. Nanopulberi magnetic dispersible in biological fluids
Q3.3. The technology of laser processing for the realization of devices, microfluidic
Q3.4. The bandages of the type of hydrogel loaded with chemotherapeutic drugs
Q3.5. The technology for the manufacture of the stent biliary tract
Q3.6. Protocols for the analysis of cells exposed to ionizing radiation

WP4: manufacturing Technology, advanced sensors and software sensing for smart agriculture, and public safety.

Q4.1. The platform imaging multiscală for the analysis of the microstructural components are active, in the advanced configuration of a battery pack (e.g., welding, laser)
Q4.2. Platform for the monitoring of the effects of the stress factors in plants, as in the area of smart agriculture
Q4.3. The platform for monitoring and controlling the processing parameters of the technological installations of plasma
Q4.4. Device senzoristice dedicated to the detection of gases with a risk for your use of the domestic and the public
Q4.5. The platforms for the detection of gaseous compounds specific to the processes of decay and ripening of the fruit storage
Q4.6. The platforms for the detection of pesticides in water and soil
Q4.7. Platform for the imaging of the test, and the determination of the operating conditions of the battery (in-situ/in-operando)
Q4.8. Platform for the monitoring of temperature in order to control the quality of the manufacturing processes of advanced

Expected results

The results of the project will pursue three goals: i) to excellence in science, ii) the performance of the industry and iii) the 'societal challenges'. The results of the estimates are collected in the scheme of the embodiment, and are associated with the phases of the project. For the period of the 2023-2026, indicators, measurements are proposed for the verification of the results of the estimates are:

1. ISI articles / papers in the international conferences of the relevant
2. The proposals of the patent
3. The designs of the experimental/lab samples
4. Technical concepts/ Prototypes
5. Studies/Procedures/protocols, we
6. Technology/product
6. The development of new services for high-value-added
7. Development of projects and technology transfer
8. Preparation of the project proposals of Horizon Europe
9. The development and management of projects in the PNCD IV, as a function of the number of calls.

Added to this are:

To strengthen the capacity of teams from research and development to participate in national and international projects, and in particular the president of the council, for the continuation and development projects with international partners, for the purpose of research and development, services, technology products, we are;

In addition, the project will also create opportunities for the professional development of young people involved in the implementation of the project and helps to develop the human resources of the research. The obtained results may lead to the issues of the modern works of the masters, and doctoral levels. It will aim to attract a targeted group of partners in the scientific and business (with a preference to those who have expressed an interest in the research directions of the project) in order to build partnerships, and the potential for companies that are interested in taking over the patent in order to obtain the rights to use it.

The scheme of realization of the project:

The year of 2023 – the output of the PN-23 03 01
- Phase I
The year of 2024 – the output of the PN-23 03 01
- Phase I
- Phase II
2025 – the output of the PN-23 03 01
- Phase I
The year is 2026 – the Schema of the output of the PN-23 03 01

The year of 2023 – the output of the PN-23 03 01

Phase I

Contract no.: 30N/12.01.2023
Title: "The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society"

Step 1: "The development of the sub-assemblies and components for laser pulses of sub-picosecond"

Responsible for this: Dr Marian ZAMFIRESCU

The term of the conclusion of the phase: 12.05.2023

Abstract:
The main objective of this phase was the study of various configurations of optical sub-assemblies, and components of the optical and electronic characteristics of the amplifier and laser pulses of sub-picosecond, as well as the realization of the elements of the laser-pumped (the medium-the active laser, the mirrors of the laser) to get the configuration of the system, the laser end. They have been carried out for the first time by the Czochralski method, and were characterized by crystal laser type Nd:LaxGdyYzSc4-x,-y,-z(BO3)4, with the melting incongruentă, and the emission of the laser's effective at 1.06 µm. They have been designed for the configurations of the structure and dielectric Bragg, for making mirrors and laser are obtained, and the characterization of thin films of SiO2, TiO2, and HfO2 deposited by the techniques of PID, value added tax and magnetron sputtering, and were determined the parameters of the optical film made. There have been developed a number of numerical studies based on finite-difference (FDTD) in order to determine the environments, the optimum for the propagation of the laser beam to induce an elongation time of the laser pulse in the field of 0.5 – 1 ps. Also, there have been developed a number of models raytracing for the design of a scheme, the best of the amplifier of the laser in order to achieve a maximum efficiency of the amplifier according to the current requirements in the field of the laser pulse of ultra-short. The target is an intermediate step in the realization of laser sources for the production of advanced additive and subtractive devices for emerging technologies.

Abstract this graphic:

Step 2: "Synthesis and characterization of the active materials used in advanced sensors and sensing"

Responsible for this: Dr Gabriela CHRISTMAS

The term of the conclusion of the phase: 15.07.2023

Abstract:
As part of this step was performed on the synthesis and characterization of materials used in advanced sensors, and detection methods with the laser, plasma and radiation. We have obtained and characterized oxide nanopowders with a low content of carbon by the pyrolysis of lasers, phosphors (SrLaGaO4, Ca3Ta2Ga3O12), ceramic difuzante, and the luminescent material doped with the ions of the lanthanide (Nd3+, Er3+, Ho3+, Yb3+), nanopereți carbon (CNW) are either simple or functionalized by the technique of plasma, and the nanoparticles with or without the magnetic properties (nAg nNi), by irradiation with electrons accelerated to high energy.

For the senzoristicii of the gas have been synthesized oxide nanopowders by using isopropanol and etena as sensibilanți. The use of isopropanol in the form of a vapor, it has led to a decrease in the size of the crystals of SnO2-x, with 23% as compared to the process in which it is used etena. Also, they had come up with nanopulberi of SnxFeyOz of 4.5 nm with the crystallinity, the good, the size of the crystal varies between 3 and 10 nm. For the senzoristicii surface acoustic waves (SAW) have been synthesized TiO2 nano-particles by the method of pyrolysis of the laser in the fumes of TiCl4 in the air and in the presence of ethylene, in varying operating pressures, the average size of the particles, as expected within the range of from 15 to 22 nm.

Also, the obtained phosphors ceramic Er:CaSc2O4 (via the sol-gel method), RE3+:CTGG and the RE3+:SrLaGaO4 (by way of reaction in the solid phase). We have chosen three of the matrix of the host (Y2O3, CaSc2O4, and BaGd2ZnO5) prepared by the method of the reaction in the solid phase, and which have been doped with the three systems, the ions of the lanthanide (Er3+-Yb3+, Ho3+-Yb3+ - and Er3+-Ho3+-Yb3+), resulting in materials with crystallinity of pure, who confirmed the emission, in the area of 500 to 800 nm. The analysis of the structural and morphology have shown the properties of the favorable characteristics of these materials for applications such as temperature sensors, non-contact.

It summarizes the nanopereti of carbon dioxide (CNW) are either simple or functionalized by the techniques in the plasma of RF, in many different kinds of supports, in order to obtain the cell that would stand on its own feet. They have been identified and tested the effects of the CNW, with applications in the field of senzoristicii SAW the gas sensor chimioresistivi and it shows.

The optimization of the process of irradiation by the application of an experimental design, Central Composite Design (circumscribed) – Response Surface Methodology (CCD-RSM), with 20-position, has led to the obtaining of nanoparticles of silver (nAg) to the radiation dose of 17.6 kGy, with a desirability of 0,810. The nanoparticles of nickel (nNi) with the magnetic properties have been obtained at the irradiation dose of 300 kGy, their size varying between 20 and 70 nm of torque.

Abstract this graphic:

Step 3: "The development of methods and protocols for the detection, with applications in smart agriculture"

Responsible for this: Dr Gabriel SOCOL

The term of the conclusion of the phase: 13.10.2023

Abstract:
The contamination of soil with heavy metals is a major concern in terms of pollution to the environment, having a negative impact on the growth of the plant, the quality of the food, and the health of the animals, and the general public. For the achievement of the objectives of this phase of the effort has been focused on the effect of copper, the metal that was used in the pesticides commonly used in agriculture, the impact on the development of the plant and the soil.

Thus, it was investigated the effects of contaminated soil on the plants grown in this medium. In order to identify the concentration of copper in soil samples, were used in spectroscopy techniques, Laser-Breakdown Induced Spectroscopy, and Time-Domain Spectroscopy in the THz domain, by developing the two protocols for the detection of contaminants in the soil. It has been developed and used in a growth chamber with dimensions of environmental control for the study, 125 plants, then Data were grown in the contaminated soil. The light conditions, temperature, and moisture content of the soil was kept constant, being monitored, the effects of copper on these plants, with the help of UV-VIS spectroscopy and imaging Investigations. In this respect, we have developed a specific protocol for the monitoring of the effects of the samples from the contaminated soil, the plants, by using these two techniques complement each other.

At the same time, he developed a protocol for germination contained the seeds of common wheat were determined from the concentrations of ethylene and ammonia in the breath of the germ of the wheat (Triticum aestivum) by using the technique of spectroscopy fotoacustică with a laser beam. The contamination has been carried out in a controlled using a solution of CuSO4 at concentrations in molar ratio of 1 µM, 100 µM, 1 mM and 10 mM. On the other hand, we have studied the effect of the remediation of the hidrogelului the geremenilor of wheat germinate in the soil mixed with the hidrolgel, and two different types of food. Thus, the same technology absorption spectroscopy has been applied to the evaluation of the influence of the contaminants from the type of heavy metals on germination, rooting, rising, and the fellowship of the seed of the wheat in the ground, and the hydrogel was observed beneficial effect of bioremediation on the seedling emergence of wheat.

During this phase, there have been developed: i) a protocol for the determination of the sensitivity of the sensor to the FO-SPR coated with gold, using a two-fold dilution of the sucrose with a refractive index for the met, and ii) a protocol for the FO-SPR on the basis of reflection, covered in gold-functionalized with PANI, which is able to detect Cu2+ in deionized water, with a sensitivity of 2379 nm/mM, and a LOD of 0.35 µM.

These studies have contributed to our understanding of the impact of the contamination with heavy metals on the environment and provide cost-effective methods of detection.

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Stage 4: "Job-state lasers, plasma and radiation damage of the structures, biomaterials, implants, and wound dressings Loaded with the chemotherapeutic drugs"

Responsible for this: Liviu-Marian DUTA, Alexandra PALLA-PAPAVLU

The term of the conclusion of the phase: 08.12.2023

Abstract:
At present, there is a significant application for the manufacture of a medical device intended for application in regenerative medicine, which is part of the advance of personalized medicine. In this context, the technology behind the stent biliary disease is becoming an essential element that contributes to the successful implementation of the procedures for liver transplant recipients, and facilitate the rapid recovery of the patient. In this context, we report the fabrication of a new design of the device is a stent in the bile, based on polycaprolactone (PCL), fully resorbable, primarily designed to support the functions of the bile duct in the post-liver transplantation. We present the results of a study investigating the effects of time and speed of centrifugation on the morphology of thin films of PT produced by the coverage of the centrifuge. In the end, the PCL has been divided by the irradiation with the radiation of the laser polarized linearly.
X-ray diffraction patterns GIXRD of the layers of the thin BioCaP summary showed that the presence of a single phase of HA-type socket. It has been observed that the degree of crystallinity of the structures of the synthesised has been affected by the deposition parameters. The FTIR spectra showed the existence of bands of the phosphate group, the specific structure of HA, okay, crystal. This result is in agreement with the observations of GIXRD. The results of the investigation, the SEM has been demonstrated in the synthesis of surface morphology is rough and rugged, consisting of the parties (" particulate matter ") from the shape of the ball, or even ovoid, with different sizes. SEM images of cross section are shown in all cases, the coatings are uniform, with an increase in the type column. In contrast to the control, for which he recorded the behavior of a water-repellent, in the case of the layers of the thin-BioCaP was observed behavior of a hydrophilic. The values obtained from the tests of the bonding strength was higher than those required by the standards in force (>15 MPa).
I've got two different types of composite biomaterials functionalized: PVP ciclopirox / caspofungin acetate. Nanomaterials have been put together in the form of thin films by the method of evaporation, pulsed laser-assisted matrix (MAPLE) on substrates of silicon and the optical glass. Movies the thin deposited by the MAPLE leafs have been characterized by AFM and ft-IR.
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Abstract this graphic:

Phase 5: "The manufacturing of the laser to be additive, and the texture of the structures made of biocompatible materials"

Responsible for this: Irina PAUN, Andrei POPESCU

The term of the conclusion of the phase: 08.12.2023

Abstract:
Phase 5 of the project, the targeted production of laser additive and the texture of the laser structures made of biocompatible materials. To accomplish this goal, it had been planned and carried out a 3-on activities, all of which application to direct you in the biomedical field. The production of laser-added method to the Melting of the Laser selectively resulted in the obtaining of materials for medical devices and the type of the prosthesis of the hip, based on the material of the base in the form of spherical particles of an alloy of Ti grade 5 (Ti6Al4V) with a diameter of between 20-63 µm. In order to obtain dense structure, without the flaws of the interior of the main process parameters have been: 200 W, the power of the laser, at a processing speed of 2 m/s, which is a layer having a thickness of 20 µm. It provides a structure metalografica type of Widmanstatten with the dendrites of the phase α, the hexagonal compact, grown in two directions perpendicular to the in-phase β-cubical volume in the center. These results can be scaled up for use in your applications, medical engineering, in particular for a large range of implants and perosnalizate. The shape and dimensions of the products of the individual can be achieved by using the tools of 3D scanning with X-rays (ct scans of the patients). Another task was to develop a protocol for the fabrication of the laser added through a method of writing to direct the laser through a photo-polymerization of 2-photon structures, 3D-architectures, do, on the basis of a biocompatible polymers, in view of applications in the engineering of bone tissue. The motivation for this study was based on the fact that the manipulation of biological materials at the cellular level, this is an area of research of great interest for biomedical applications. As part of this activity, the structure in the form of micro-vessels have been manufactured with the use of writing is to direct the laser through a polymerization process with two-photon, of a composite on the basis of the photopolymer biocompatible nanoparticles are superparamagnetic, on the basis of oxide of iron. The structures obtained have been characterized from a structural point of view, and tested in cell culture-type osteoblasts. The structures of the seeded cells are exposed to static magnetic fields of about 1.3 T were approximately 5-fold more efficient in terms of the trapping of the cells, in comparison with the structures of the nestimulate in a magnetic field, demonstrating their potential for the engineering of bone tissue. The third activity is carried out in the framework of the Phase of the target throughout the biomedical field, specifically the development of new technologies asitate innovative laser in order to improve the efficacy of implantable devices. This type of activity to explore the development of an experimental model of microprelucrare with the laser and the excimer by the projection of the mask, and the replication of the surface microstructurate (PLGA, chitosan, PCL, Zirconia), which has been tested and validated in vitro, in cell cultures, and for which he got a response of the biological preparation. This approach has opened new perspectives in the development of implantable devices custom made with high potential for integration, and compatibility with biological improvement, and contributing to the progress of the applications of bio-medical.
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The year of 2024 – the output of the PN-23 03 01

Phase I

Contract no.: 30N/12.01.2023
The project: "The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society"

The phase 6/2024: "The techniques and devices advanced analytics for personalized medicine"

Responsible for this: Dr - Felix SIMA

The term of the conclusion of the phase: 09.05.2024

Abstract:

  At this stage, I have been following the development of new methods and techniques of analysis for personalized medicine. There have been three studies in order to achieve this goal.
  • In a first study, we showed that the techniques for processing with a laser pulse of ultra-short-materials allow you to improve the resolution of the micro - and nano-manufacturing, and it has the advantage of obtaining some of the issues with the size of the hierarchy as compared to the techniques of lithography. In addition, I managed the integration of the systems of the micropompaj in microfluidic production of electrodes of ITO, with a controlled size. Devices, microfluidic, and nanofluidice offers solutions that are ideal for the observation of the ability of cancer cells to migrate through tight spaces, which mimics the processes of the intravazare-extravasation from the in vivo studies.
  • We have analyzed the specific features of a fingerprint, using the dust Er(x,%): BGZO. The aim of this study was the preparation of a material is chemically stable and heat, the properties of the luminescent particular, for the conversion of the high to the low power of the plant in the near-infrared. For this purpose, we have investigated the properties of the emission by the conversion of the upper pool, to the material, the type of BGZO doped with the ions in the Er3+. The most promising results have been obtained on a sample of BGZO whacked out of 4 at% Er3+. The study of the residue left behind from the surface of the finger on the blade giving you the opportunity to use your fingerprint in personalized medicine, reflecting the transition from a "one-size-fits-all" to custom, and dynamic.
  • The research in this study has been focused on three different types of cancer, in the field of ENT: squamous cell carcinoma microinvaziv at the level of the hemibazei of the tongue squamous epithelium-mioepitelial with the activity of the mitotic focal increased to the level of the floor of the maxillary sinus, and squamous cell carcinoma poorly keratinizant G3 at the level of the hemilimbii. The obtained data contribute to the identification of the significant parameters, such as the intensity of the maxima of the fluorescence, and time-to-live, you autofluorescenței, which can be used in the discrimination between healthy tissues and malignant tumors in the field of ENT. Thus, the integration of the analysis of the autofluorescenței, and of ft-IR should be able to improve the ability of the diagnosis and characterization of neoplastic hearing aid, with a great potential in the field of medicine.

Abstract this graphic:

The phase 7/2024: "The completion and testing of the components of photonics and electronics of the control system of the laser pulses of sub-picosecond"

Responsible for this: Dr Nicholas PAUL

The term of the conclusion of the phase: 06.06.2024

Abstract:

  • As part of this phase of the contract, has been obtained the emission of the laser efficiency (at 1062 nm) and a crystal came to pass, When The_xGd_yY_zSc_4-x-y-z(BO₃)₄ (Nd:LGYSB), using the pumping of the optical diode lasers. It has been investigated in the regime of the operating system free with the pumped quasi-continuous and continuous.
  • We have obtained and investigated in a sample of the ceramic-type Ca3(Li,Ta,Ga)5O12 – (CLTGG) doped with different concentrations of Tb3+. It has been estimated the effective emission at 542 nm, the value obtained (2.54×10-21 cm2) indicate that the type of CLTGG:Tb (15 at.%) it may be a potential environmental asset for the emission of the laser, at 542 nm of torque. They have been obtained and investigated in the samples of ceramic co-doped type-CLTGG:Tb (15 at.%), Yb (y, at.%). They are made with the identification of emission of Tb3+ in the visible spectrum, with excitation in the infrared (at 973 nm). The environment of the ceramic doped with Tb (15 at.%), Yb (5 at.%) the most intense line emission at 542 nm of torque.
  • They were obtained by the average of the ceramic, transparent, composite-type Y2O3/x-at.% The Nd:Y2O3 (x= 0.5, 1.0, 1.5), and Y2O3/y at.% The Yb:Y2O3 (y= 3.0, 5.0, 8.0), by reaction in the solid phase sintering, in several stages. The averages of the ceramic shows a high quality that is confirmed by the results obtained from the investigation of the structural, morphological, and optical.
  • They've been made out of mirrors of the laser at 532 nm by the deposition of thin films of TiO2 and SiO2 on the substrate by the quartz crystal by the method of RF-magnetron sputtering. They were obtained by the mirrors of the laser, with the 7th, the 11th and the 17th of the layers, using the substrate of the industrial office. All of the videos submitted, presented the the very best quality in terms of surface roughness, villosities, measured by AFM, profilometrie and elipsometrie is of the order of the subnanometric up to a few nm. It was carried out a parametric study in order to optimize the obtaining of reproducible, mirrors, Bragg (heterostructures of TiO2/SiO2/TiO2/SiO2/TiO2/SiO2/TiO2 layers on a substrate of quartz crystal) on a large area by the submission of the laser-pulsed (PLD and RF-PLD), covering the reflectance at a wavelength of 532 nm. It has been obtained by PLD and RF-PLD heterostructures containing a 7-alternating layers of SiO2/TiO2 layers on a substrate of silicon, thick, and dense, with a surface roughness is very small~3 nm of torque (IT) and ~9 nm (AFM)]. They have been made structures such as multi-layer (TiO2/SiO2)×3 (TiO2/SiO2)×7, using the method of the VAT rate in the controlled atmosphere of oxygen.
  • It has made the design of the system, the laser pulses of sub-picosecond, and a system of command-and-control for (a block diagram of the overall control including the timing, selection, and implementation; the structure of the system of command and control, interfaces, input and output).

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The phase 8/2024: "The integration and characterization of the structures of the sensors"

Responsible for this: Dr Alexandra Palla-Papavlu

The term of the conclusion of the phase: 26.07.2024

Abstract:

  The agriculture of today is faced with many challenges, including a lack of manpower, the unpredictability of the climate and the soils are poor in the case of the management of scarce land. In order to address these issues, the technology provides the solutions through the development of sensor platforms for the detection for smart agriculture. This project focuses on the development of technologies for the fabrication of sensors and platforms for sensing, covering both smart agriculture, as well as the safety of the public, along with the monitoring and quality control of manufacturing processes advances.
  Within the framework of the project have been achieved in experimental models of sensors with thin films of the solid solutions piezo-electric, for the detection of gases such as CO2 and NH4. Thin layers of barium titanate (BaTiO3) have been deposited on ceramic substrates of alumina (Al2O3) by the laser ablation (PLD) and characterized for their morphological, chemical, and electrical. The tests showed jumps in a significant frequency in the presence of the gas, thus demonstrating the importance of the deposition parameters.
  Also, we have fabricated sensor conductometrici on the basis of metal oxides (SnO2-ZnO), and polianilină (PANI) for the detection of methane in the temperature of the room. The electrodes of the metal from the platinum was deposited by sputtering, and the sensitive material has been added by the PLD, and curing the oxidative chemical (PANI).
  The technique of the LIFT (transfer of the laser-induced forward) has been used to fabricate sensors, chemorezistivi-based materials, organic-inorganic hybrid (PEDOT:PSS-GO). This technique has allowed for the transfer of a specific material on a substrate receptor, resulting sensors are able to detect NO at room temperature.
  In order to improve the chemical and physical properties of the sensor, we used the γ-irradiation with a beam of accelerated electrons. This process was performed with a linear accelerator of electrons, and the dosimetry was accurately monitored by using the calorimeters of the lead and the film radiocromice B3, calibrated in accordance with the international standards.
  In conclusion, this phase has demonstrated success in the development and characterization of advanced sensors for smart agriculture. The use of technology such as a PLD, an ELEVATOR, and the irradiation of the electron beam of the led to the production of sensors, adaptable, able to respond quickly and effectively to the presence of the gas of interest. These achievements can make a significant contribution to the improvement of the monitoring and control of the processes of agriculture, and promoting the agriculture more efficient and sustainable.

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The phase 9/2024: "Study of the analytical and experimental results for the optimization of the properties of the nanofluidelor magnetic-functionalized compounds for antitumor"

Responsible for this: Dr Florian DUMITRESCU, Phd. Angela STAICU

The term of the conclusion of the phase: 07.11.2024

Abstract:

  We investigated the nano-particles of iron oxide prepared by the pyrolysis of the laser by using a different senzitivanți: ethylene (NPs), isopropanol (i-NPs), and ethanol (eNPs). The analysis of the morpho-structural, confirming the presence of a material the materials of the small, quasi-spherical, with a tendency of agglomeration is connected. All of the powders showed a high stability in water, and the size of the diameter of a hydrodynamic low. It has achieved stability/functionalizari with dextran, CMCNa, Decarbazina and Folic Acid, and the optimization of these protocols. Heat-treatment of the nanoparticles is carried out in order to generate their magnetic properties, high over the specific value of the newly synthesized without compromising the ability of their suspension. Nanopulberi of γ-Fe2O3 were synthesized by the pyrolysis of the laser by using ethanol as a senzitivant, and subsequently they are heat treated to 250oC, 3 hours in a steady stream of gases: air, Ar, and air. The structural changes are minimal, if the treatments are done with It, or the air, but the size of the crystal increases significantly, from 5.2 nm for the untreated to 13.0 nm for NPs-treated in a hydrogen atom. Nanofluidele prepared with these NPs in water, it shows an excellent stability in time, the testing was done after 1 hour and 24 hours after the preparation, the size of the agglomerate is.c.it. 100nm, and the Zeta potential more than 45mV. Heat treatment affects the reasonable time for a little stability, but reduces the Zeta potential.
  They have been studied in emulsions, including fotosensibilizatorul of the TPP-SO3Na-and nano-particles of e-Service, i-NPs, NPs loaded with Dacarbazine. They have been analyzed from the point of view of morphological, structural and physico-chemically by the special investigation unit, absorption spectroscopy, UV-Vis, ft-IR, TOP, phosphorescence of singlet oxygen is generated, and the analysis of the surface tension of the dynamic.
  The results of DLS showed that the emulsion size is stable, the droplets are between 150-170nm, which remains constant for the duration of the experiments, indicating that the stability is very good. The stability of the emulsions was confirmed by the analysis of ft-IR-ATR. One of the emulsions considered, the challenge to the stability of the was the emergence of the TPP-SO3Na+and-Service.
  The tests for the generation of singlet oxygen, they found a significant amount of time, the intensity of the signal from the stuff of the latter in the emulsion as compared to the simple out of the TPP-SO3Na. The analysis of the dynamics of the surface tension indicates that there is a migration of a significant particles of the dispersed phase to the surface by the coalescence of droplets of the oil and the emulsion leaves a uniform and stable.
  In conclusion, the emulsions studied the embedding of the nanoparticles shows a remarkable stability and can increase the rate of generation of singlet oxygen, which is what I recommend for the potential applications in the therapy pdt for the efficient delivery of the drug.

Abstract this graphic:

The phase 10/2024: "Optimization of technological processes for the synthesis and fabrication of components for the storage of energy, the partial phase"

Responsible for this: Dr Mihai ZAMFIR, Phd. Nick SCĂRIȘOREANU

The term of the conclusion of the phase: 22.11.2024

Abstract:

  A method for the pyrolysis of the laser has been used for the synthesis of anodic Co for all types of ion-Li-or Na-based mixtures are controlled by the nanoxizi tin (SnO2 and SnO) in terms of Sn(CH3)4, and using the senzitizer/carrier, C2H4 in the presence of the various streams of the O2 (+N2). The properties of the morphostructural, composition, and dispersion in the lichideau been reported, by using the techniques of XRD, EDS, XPS, TEM, and DLS – Zeta Potential
  The method of a substrate coated with a catalyst (ASC) has been used to make MY own for the PEMFC. The layers of diffusion of a gas (GDL), are constructed by covering the paper out of carbon fiber, corresponding to the size of the layers mezoporoase (MPL) forming a suspension of the nanoparticles in the carbon-in isopropanol, with a small amount of perfluoretilenă water-repellent spray airbrush. Then, the catalyst (CL -) that was produced from the pyrolysis of commercial or laser-made nanoparticles, carbon-based and decorated with various amounts of ultra-fine particles of Pt for the cathode and the anode, and added with a fluoropolymer-sulfonate are sprayed across the MPL are low. In the end, the electrolyte, the polymer is commercially pressed up against the warm-up between two of the CL-backed on the GDL in order to get MINE functioning.
  Calcogenurile of the transition metals (TMCs) stands out as one of the most interesting candidates for both fundamental research and potential applications in the field of energy in the body. Their synthesis in the form of nanostructurată and architecture, straight, with carbonaceous materials have enormous potential, mainly due to the high ratio between surface area and volume, which provides a space for accommodating the volume changes during cycles of loading and unloading, while promoting at the same time, the transport of the ion-quick and interactions of the short distance between the load, which allows for a high rate of charge/discharge. For the realization of these architectures, nanostructured materials have been used, the methods and techniques with a high degree of scalability, and the potential for the transfer of technology partners in the industry: the plasma of the Arc-type Thermionic Vacuum tax (VAT), the deposition of the vapour-assisted laser (LCVD) and sulfurizarea of the hot spring.

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Phase II

The phase 11/2024: "The development of methods for the prediction of the disrupțiilor in the plasma of a fusion, through the analysis of the signals, which describe the evolution of the topology of the configuration of the magnetic"

Responsible for this: Dr Teddy CRACIUNESCU, Phd. Edward GREGORY

The term of the conclusion of the phase: 08.10.2024

Abstract:

Commissioning and start-up of new plants tokomak of the major makes it all the more necessary for the development of effective methods for the prediction of the disruptiilor of the plasma to fusion. The tools it would need to be not only accurate, but also able to work with a minimum number of signals, as in the first campaign of experimental systems, it is usually available for only a very limited number of diagnoses. It has been developed a method based on statistical techniques to advanced, for the detection of the changes of the paradigm shift in the time series generated by the system to diagnose the plasma. This method is able to detect the movement of the plasma to the region operating in hazardous, using only the signals of the global signal, diagnostic, which describes the stability of the configuration of magnetic fields and the power of the plasma. The performance of the results obtained meet the requirements of the specific prevention of disruptiilor in the devices, as well as the JT60-SA, and the ITER at the beginning of the functioning of these. The method offers a high rate of correct predictions (about 98%), positives, missed on the order of a few per cent and the false alarms in the order of 10%. The method is able to provide predictions by about 400 ms before the disruption, which is why it's a comfortable, which allows for the termination, in a controlled discharge.

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The phase 12/2024: "The realization of the sources of plasma, with the use of in-process materials, and preliminary testing of the functionality of their own – a partial phase"

Responsible for this: Dr Rolo POROȘNICU

The term of the conclusion of the phase: 22.11.2024

Abstract:

  In the framework of the current phase of the project the method used for the investigation of the turmoil brought about by an electron beam with energy of 13 keV in the plasma, complex (dusty plasma).The identification of the position of each particle in the frame of the window was made by applying the function to the correlation and interpolation space of the bi-linear. By using the Particle Tracking Velocimetry (PTV) has been identified, the trajectory of the exact day of each particle. It can be observed that the starting of the electron beam generates a stream of tiny particles, which increases gradually over the first 50 ms of both the speed and the size. After more than 100 to 200 ms, it starts the second gears with symmetric enlarged to the full size of the crystal, with a maximum speed of 12 mm/s, in the centre of the stream.
  One of the main goals of this phase was to test the operation of the equipment is named as the Source of power for generating the plasma (SAGPR), which was made in the course of the previous stage, in various operating conditions, in accordance with the requirements of the state on the basis of its design. SAGPR has been designed as a piece of equipment out of the laboratory, universal and versatile, with the purpose of supplying electric power to a wide range of devices, plasma generators, which are provided with electrode systems with various sizes and shapes that can be, to some extent, arbitrary.
  In the framework of the NILPRP (Laboratory of Plasma Temperature is Low, the group of Processes in the Plasma, because the Material of the Functional Surfaces) has been implemented in the last few years, a new mode of operation of the source is achieved and the metal (W), such as MSGA. Thus, in our experimental conditions-specific, plasma is the source of the creeping out through the aperture of the output, along with the nanoparticles. Experiments with primary setup is a critical component of the operation MSGA-JET: for certain values of the parameters, the plasma has an unstable character, the inadequacy of the processes for the synthesis of nano-materials. At this stage it was carried on the research of the way the MSGA-JET. Results of the laboratory tests have led to the identification of the range of the parameters for this operation, stable source of MSGA-JET. These activities correspond to the level of maturity of the technology's TRL 3. The identification of the scope of the operation is stable to the source of the MSGA-JET allows for the further development of the method for the synthesis of nanomaterials.
  It has been designed and tested for the source of the plasma at the atmospheric pressure of the jet, with a double shot below and postdescărcare for the synthesis of nanocomposite materials, which provide independent control of the composition of the matrix polymer of the type of polysiloxane, and that the concentration of the metal in the structure.

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2025 – the output of the PN-23 03 01

Phase I

The phase 13/2025: "Experimental and analytical work for the development of wound dressings for the type of hydrogel loaded with chemotherapeutic drugs"

Responsible for this: Dr Maria DEMETER, Phd. Angela STAICU

The term of the conclusion of the phase: 09.04.2025

Abstract:

Multifunctional systems for the administration of drugs with a new strategy in the treatment of the target in cancer, as these will give you the advantage to the administration of chemotherapeutic agents, without damage to cells and tissues healthy. In this paper, we developed and characterized for the new polymer compositions of the obtained poly(vinilpirolidonă), carboxy methyl cellulose, poly(ethylene glycol), agar gum, gellan for the development of wound dressings in the form of a hydrogel loaded with chemotherapeutic drugs. Hidrogelurile have been simultaneously synthesized (cross-linked), and sterilized by irradiation with the electron beam at a dose of 30 kGy. To demonstrate the functionality of the hidrogelurilor developed countries has been achieved through the analysis, sol-gel, the efficiency of the process of cross-linking, swelling properties in a physiological environment, and the tumor simulated, with a capacity to hold moisture, structural analysis (ATR-FTIR), rheological properties, degradation in vitro, the ability to load anticancer drug (5-FU) and the profile of the in vitro release of 5-FU. The kinetics of the release of 5-FU have been investigated using a mathematical model commonly used in the design of pharmaceutical drugs. After the irradiation, the hidrogelurile are a fraction of the gel is 90%, and the cross-linking process is predominant. The high values of the yield radiochemical cross-linking (330 µmol/J), a 16-fold higher than those from the decay of (20 µmol/J), confirming the formation of the hydrogels cross-linked with the role of the main character after the irradiation. The environment of the swelling significantly influence the degree of swelling, and the ability to charge with the 5-FU hidrogelurilor. In an alkaline medium, the absorption capacity is 980-1090 %, and the pH is significantly higher, 1380-1580 %. Hidrogelurile preserve approximately 48% of its moisture for up to 8 hours, more than enough time to ensure the functionality of it as the dressing for type in the hydrogel. The analysis of the rheological showed that the hidrogelurile have a behavior that is predominantly elastic, specifically a network of high molecular weight cross-linked (F’ = 3 450-54 000 Pa). The capacity of the optimum loading of 5-FU, varies as a function of pH, time of upload, the composition of the hidrogelului, and the concentration of 5-FU, 200 mg/L of 5-Fu and 30% at pH 6, and 29% at a pH of 5. The release of 5-FU was slow at pH 7.4, making it gradually up to 80% full in 30 hours, depending on the composition of the hidrogelului. The kinetics of the in vitro release of 5-FU correlated best with the kinetic models, Korsmeyer-Peppas, Peppas-Sahilin and the Makoid-Banakar (R2 > 0.99) and demonstrated that the release of 5-FU is governed primarily by the mechanism of accelerated, followed by a mechanism that is controlled by the diffusion process.
The experimental results demonstrate that the hidrogelurile obtained by the irradiation of the claim to the loading and the release of anti-cancer drugs and have the potential to be used as a dressing for the local treatment of cancer.

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